BASE eDITING tECHNOLOGY
Base editing enables precise modifications to DNA by converting one DNA base pair to another, without introducing double-strand breaks. This innovative technology offers unparalleled accuracy in genome editing, opening new possibilities for targeted genetic modifications with reduced off-target effects.
Precisely Alter Base Types with Base Editors
Base editors are molecular tools capable of precisely altering the genetic code by changing individual bases within the DNA sequence.
Targeted AID-mediated mutagenesis (TAM)
TAM base editor contains a fusion protein of nickase Cas9 and activation-induced cytidine deaminase (AID) with/without UGI , and a single guide RNA (sgRNA). TAM base editing tool can convert C:G base pair to T:A base pair at DNA level.
Expanding Therapeutic Horizons
DNA mutations underlie over 8000 known genetic diseases. Base editing holds promise as a potential effective treatment.
